Adenoid cystic carcinoma of head and neck: A single institutional analysis of 66 patients treated with multi-modality approach

Adenoid cystic carcinoma of head and neck: A single institutional analysis of 66 patients treated with multi-modality approach

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Background: Adenoid cystic carcinoma (ACC) accounts for 1% of all head and neck (HN) cancers.Materials and Methods: Demographic, clinical, treatment, and survival details of 66 patients were collected (1995-2011) and analyzed.Disease-free survival (DFS) was estimated by Kaplan-Meier method.Results: Primary disease sites were sinonasal (n = 27), salivary gland (n = 30), and others (n = 9).Median follow-up was 23 months Heavy Duty (range: 12-211 months).

Estimated DFS at 2- and 5-year were 75% and 67.2%, respectively.On univariate analysis, intra-cranial extension (ICE) (hazard ratio [HR]: 3.59, P = 0.0071), lymph node involvement (HR: 4.

05, P = 0.0065), treatment modality (others vs.surgery plus adjuvant radiotherapy, HR: 2.39, P = 0.0286) and T stage (T3/4 vs.

T1/2, HR: 3.27, P = 0.007) had significant Matchy Match impact on DFS.Lymph node involvement (P = 0.038) and ICE (P = 0.

038) continued to have significant impact on DFS on multivariate analysis.Conclusion: Surgery followed by adjuvant radiotherapy remains the treatment of choice for HN ACC.Lymph node involvement and ICE confer poor prognosis.